During HoW I ended up running 4/5 rounds of the 28 PoE with a random girl. Our 3rd dropped out after Round 1, and we just went for it. We were both defender titans, she had Weapons, I had Armor, just by chance. We completely Rekt it without mics with insane synergy. I didn't find out it was a girl til afterwards. The experience led me to this conclusion: Gender is irrelevant. Anyone can be badass in Destiny. :)