Occurs 90% of the time with any bosses in those room, causing them to despawn and infinite waves of Thrall to spawn and/or bombs to spawn.
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Hey there, Thank you for reporting. We'll pass this along to the developers for investigation.
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Update: It may have something to do with Area Denials/Anarchy/Witherhoard. Took it off next run through and the glitch didn’t happen but cannot 100% confirm